De Britse acteur Rhys Ifans (Notting Hill, The Boat That Rocked) gaat de villain spelen in de Spider-Man reboot van regisseur Marc Webb. Dit is bekend gemaakt door de maatschappijen Sony Pictures Entertainment en Columbia Pictures. Wat nog niet bekend gemaakt is, is de rol die Ifans moet gaan spelen. Regisseur Webb: "What sets the Spider-Man villains apart is the complexity of their relationships with Peter Parker. Rhys' incredible ability to embody both warmth and rage makes him the ideal choice for this character." Het nog onbekende karakter dus.

Matt Tolmach, baas van Columbia Pictures, over de casting: "We have been very fortunate to attract some of the best actors working today to play the villains in the Spider-Man movies, and it is exciting to see that trend continue with Rhys Ifans. After seeing his performance in our upcoming film 'Anonymous,' we're in awe of his talent and think he's the perfect choice to take on this role."

Ifans gaat het opnemen tegen met name Andrew Garfield, die Peter Parker / Spider-Man speelt en uiteraard ook Emma Stone die te zien is als Gwen Stacy.