Matt Damon is na Ocean's 11 en Ocean's 12 wederom van de partij in Ocean's 13, net als George Clooney, Brad Pitt, Matt Damon, Andy Garcia, Don Cheadle, Bernie Mac, Casey Affleck, Scott Caan, Eddie Jemison, Shaobo Qin, Carl Reiner en Elliott Gould. Ook Al Pacino is door regisseur Steven Soderbergh overgehaald, en Damon liet in vage bewoordingen weten waarvoor.

"It's kinda like a revenge thing. Someone does something to one of us and we want revenge. And that someone is Al Pacino. We have to take him down."